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Cientistas descobrem mais de 80 genes ligados à esquizofrenia

Cientistas descobrem genes ligados à esquizofrenia.

Cientistas descobrem genes ligados à esquizofrenia.
PUBLICADO EM 23/07/14 – 03h00
DA REDAÇÃO

No maior estudo já realizado sobre esquizofrenia, um grupo de pesquisadores de 35 países descobriu 80 novos genes que podem estar relacionados ao risco de desenvolvimento do transtorno. A pesquisa, publicada na revista especializada “Nature”, sugere que a esquizofrenia pode ter causas biológicas, uma conclusão que abre a possibilidade de novos tratamentos.

 

Os números da pesquisa são impressionantes. Em cooperação global, o grupo analisou a composição genética de mais de 37 mil pacientes com a síndrome, comparando-as com os códigos genéticos de outras 110 mil pessoas sem a doença. Após cruzamento de dados, descobriu-se que mais de cem genes estariam ligados à esquizofrenia, sendo 83 deles ainda desconhecidos pela ciência.

Muitos deles têm papéis fundamentais na retransmissão de mensagens químicas que envolvem o cérebro. Já outros são conhecidos por estarem envolvidos no sistema imunológico, afetando o arsenal natural do organismo contra a doença.

De acordo com os especialistas, o trabalho pode renovar o conhecimento da ciência sobre esquizofrenia, que não tem novas descobertas de grande impacto desde a década de 70.

De acordo com uma reportagem no site da Universidade de Harvard, a esquizofrenia afeta uma em cada cem pessoas no mundo, segundo estimativas. O problema, caracterizado por uma desordem psiquiátrica, faz com que seus portadores tenham alucinações e um colapso no processo de pensamento.

Em uma época em que os avanços com a genética estão cada vez maiores, pesquisas focam os genes que envolvem a esquizofrenia, devido às questões hereditárias da doença, afirmou a reportagem.

Estudos anteriores revelaram a complexidade da doença (até mesmo com evidências de que é causada por efeitos combinados de muitos genes). O novo estudo confirma essas relações e expande a compreensão da genética básica acerca da esquizofrenia.

“Por muitos anos foi difícil desenvolver novas linhas de tratamento para a esquizofrenia. Fomos prejudicados pela pouca compreensão da biologia da doença”, disse à rede BBC o professor da Universidade de Cardiff Michael O’Donovan.

Flash

Esperança. Para Gerome Breen, do King’s College de Londres, o estabelecimento de novas relações entre genética e esquizofrenia é “revolucionário”.

OTempo

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